1 The effect of reboxetine, a novel antidepressant drug that potently and selectively inhibits neuronal noradrenaline (NA) uptake, on brain extracellular monoamines was studied by microdialysis. 2 Fifteen mg kg-1 i.p. reboxetine raised extracellular NA in the frontal cortex (by 242%) and dorsal hippocampus (by 240%). 3 Idazoxan (1 mg kg-1 s.c.), given 60… (More)
Figure 4 E ect of 10 (a) and 20 (b) mg kg71 i.p. clonidine on extracellular NA in the dorsal hippocampus of rats given saline or 15 mg kg71 reboxetine once daily for 14 days. Each group is the mean+s.e.mean of 5 ± 6 rats. *P5.05 vs respective basal values (time 0). The arrow indicates drug injection.