Studies on the activity of barnase toxins in vitro and in vivo.

@article{Prior1996StudiesOT,
  title={Studies on the activity of barnase toxins in vitro and in vivo.},
  author={Tash Prior and Sandeep Kunwar and Ira Pastan},
  journal={Bioconjugate chemistry},
  year={1996},
  volume={7 1},
  pages={
          23-9
        }
}
Pseudomonas exotoxin A (PE) is a protein toxin composed of three structural domains which are responsible for cell binding (domain Ia, amino acids 1-252), translocation into the cytosol (domain II, amino acids 253-364) and ADP-ribosylation activity (domain III, amino acids 405-613). We have previously described (Prior, T. I., FitzGerald, D. J., and Pastan, I. (1992) Biochem. 31, 3555-3559) a molecule composed of amino acids 1-412 of PE and the extracellular ribonuclease of Bacillus… CONTINUE READING