Studies on the action of cortisone acetate on isolated cardiac tissue.

@article{Tanz1960StudiesOT,
  title={Studies on the action of cortisone acetate on isolated cardiac tissue.},
  author={Ralph D. Tanz},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1960},
  volume={128},
  pages={
          168-75
        }
}
  • R. Tanz
  • Published 1 February 1960
  • Medicine, Biology
  • The Journal of pharmacology and experimental therapeutics
The action of cortisone upon the isolated cat papillary muscle and isolated whole heart preparations was investigated. The results show that small doses (1 µg/ml) tend to restore the amplitude of contractions to control levels in the isolated heart preparation, and offer histological protection to papillary muscles. This effect is referred to as a "protective" or "normalizing" action. The addition of "toxic" doses of cortisone (40 µg/ml), often resulted in abnormal papillary muscle contractile… 
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