Studies on the action of cortisone acetate on isolated cardiac tissue.

  title={Studies on the action of cortisone acetate on isolated cardiac tissue.},
  author={Ralph D. Tanz},
  journal={The Journal of pharmacology and experimental therapeutics},
  • R. Tanz
  • Published 1 February 1960
  • Medicine, Biology
  • The Journal of pharmacology and experimental therapeutics
The action of cortisone upon the isolated cat papillary muscle and isolated whole heart preparations was investigated. The results show that small doses (1 µg/ml) tend to restore the amplitude of contractions to control levels in the isolated heart preparation, and offer histological protection to papillary muscles. This effect is referred to as a "protective" or "normalizing" action. The addition of "toxic" doses of cortisone (40 µg/ml), often resulted in abnormal papillary muscle contractile… 
The circulatory response to pharmacological levels of hydrocortisone.
Cardiac Active Principles in Blood Plasma
It is of interest that, although the decline of performance characteristics of in situ mammalian hearts may be due to many factors, the decline can be prevented by perfusing the coronary system of the in situ heart with blood from a healthy donor animal.
Vascular responsiveness in adrenalectomized rats with corticosterone replacement.
It is demonstrated that physiological levels of corticosterone (40% pellet) restore vascular responsiveness, body weight, thymus weight, and transcortin levels to normal in ADRX rats, whereas higher levels (80% pellets) are necessary for restoration of the baroreflex.
Should corticosteroids be used in shock?
Nutritional factors in the pathogenesis of cardiac necroses
  • E. Bajusz
  • Medicine
    Zeitschrift fur Ernahrungswissenschaft
  • 1962
The importance of K, Mg, Na and Cl in the pathogenesis of cardiac necroses and the possible role of the ionic equilibrium in the production and prevention of necrotizing cardiac diseases are discussed on the basis of experimental studies performed by the author and of previous observations described by others.
How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.
This review considers recent findings regarding GC action and generates criteria for determining whether a particular GC action permits, stimulates, or suppresses an ongoing stress-response or, as an additional category, is preparative for a subsequent stressor.
Rank‐related differences in cardiovascular function among wild baboons: Role of sensitivity to glucocorticoids
The present report tests indirect evidence for dominant males being more responsive to sympathetic catecholamines than were subordinate males, and shows that this phenomenon probably reflects rank‐related differences at both the heart and vasculature.
Changes in pituitary-adrenal activity regulate the central vasodepressor responses induced by neuropeptide Y and adrenaline in the awake unrestrained male rat.
It is suggested that corticosterone treatment can abolish the centrally evoked vasodepressor responses to close to maximal doses of adrenaline and neuropeptide Y, which may contribute to their hypertensive properties in man.