Studies on the Treponemal Immobilization Test. III. Use of the TPI as a Verification Test in Suspected Latent Syphilis*†

@article{Wilkinson1955StudiesOT,
  title={Studies on the Treponemal Immobilization Test. III. Use of the TPI as a Verification Test in Suspected Latent Syphilis*†},
  author={A. E. Wilkinson and P. J. L. Sequeira},
  journal={The British Journal of Venereal Diseases},
  year={1955},
  volume={31},
  pages={143 - 154}
}
In latent syphilis the diagnosis frequently rests purely on serological grounds, there being no clinical or epidemiological evidence to corroborate the serological findings. In these circumstances, a great responsibility rests upon the serological tests employed, and an enormous volume of research has been directed to raising the sensitivity of these tests to as high a level as possible without compromising their specificity. The application of serum testing on a mass scale to presumably… Expand
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Der Nelson-Test (TPI-Test) und andere Treponema pallidum-Reaktionen
Im Jahre 1948 publizierten Nelson und Mayer 2 ihre unter der Mitarbeit von Diesendruck und Eagan entstandene Arbeit „Immobilisierung der Spirochaeta pallida in vitro durch Antikorper, die beiExpand
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References

SHOWING 1-10 OF 30 REFERENCES
The Clinical Value of the Treponema Immobilization Test in the Diagnosis and Control of Syphilis
  • C. Chacko
  • Medicine
  • Journal of clinical pathology
  • 1953
TLDR
In the present study 532 specimens of blood sera and 56 of cerebrospinal fluid from syphilitic and non-syphilitics persons have been examined with four tests in parallel and the results obtained confirm in general the findings of earlier workers so far as the specificity and sensitivity of the T.P.I. test in the diagnosis of syphilis is concerned. Expand
Treponemal immobilization test; reliability of results for the diagnosis of syphilis.
The diagnosis of syphilis in many patients is, of necessity, made solely on the results of serologic tests of the blood for syphilis (STS). These tests have long been known to be only relativelyExpand
Biologically false positive serologic tests for syphilis; type, incidence, and cause.
TLDR
The Wassermann test for the diagnosis of syphilis was introduced into clinical practice in 1907 and has since been modified, refined, and simplfied through the use of flocculation techniques. Expand
NONSPECIFIC reactions in routine blood testing for syphilis.
TLDR
In a fourteen month period from December 1943 to February 1945 an investigation was sponsored by the Committee on Medical Research and the Venereal Disease Subcommittee of the National Research Council into the problem of the nonspecific positive (so-called "biologic false positive") reaction for syphilis. Expand
A Quantitative Precipitation Test for Syphilis
TLDR
It is desirable from all points of view to attempt to prepare an antigen which can be made in any laboratory, is specific in action, reasonably sensitive, and easy to handle. Expand
Changing Concepts in the Sero-Diagnosis of Syphilis: Specific Treponemal Antibody versus Wassermann Reagin*
  • R. A. Nelson
  • Medicine
  • The British journal of venereal diseases
  • 1952
TLDR
Virulent Treponema pallidum and the host-parasite relationship exemplified in syphilis have proved to be quite ideal as models for classical immunological phenomena. Expand
Treponemal immobilization test; results of 1,000 observations.
TLDR
To give a definite opinion on the TPI test would be premature and its study must be patiently pursued, so the present study is only provisional. Expand
SPECIFIC AGGLUTINATION OF TREPONEMA PALLIDUM BY SERA FROM RABBITS AND HUMAN BEINGS WITH TREPONEMAL INFECTIONS
TLDR
The agglutination test appears to have a specificity comparable to the treponemal immobilization test and considerably greater than the standard serological tests. Expand
An unusual case of serological discord.
  • A. Wilkinson
  • Medicine
  • The British journal of venereal diseases
  • 1954
" Serological discord" or " serological dissociation" are expressive terms used by French workers to describe the finding that different serological tests for syphilis give variable results on theExpand
Studies on the Reproducibility and Specificity of the Treponemal Immobilization Test*†
TLDR
The behaviour of the Treponemal Immobilization Test withnonsyphilitic seraisined to establish the criteria of negativity, its specificity is considered, and the conclusions reached are applied toroutine sera. Expand
...
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