Studies on the Origin of Human Leukocytic Pyrogen

  title={Studies on the Origin of Human Leukocytic Pyrogen},
  author={James J. Nordlund and Richard K. Root and Sheldon M. Wolff},
  journal={The Journal of Experimental Medicine},
  pages={727 - 743}
Release of the protein molecule, leukocytic pyrogen, is one of the many reactions exhibited by leukocytes after phagocytosis. After the ingestion of heat-killed S. albus, a 3-4 hr latent period exists, during which human peripheral leukocytes release no pyrogen, yet cellular metabolism is altered in such a way that pyrogen output may subsequently occur in… CONTINUE READING