Studies on the Mechanism of the Acute Antihypertensive and Vasodilator Actions of Several β‐Adrenoceptor Antagonists

@article{Sybertz1982StudiesOT,
  title={Studies on the Mechanism of the Acute Antihypertensive and Vasodilator Actions of Several $\beta$‐Adrenoceptor Antagonists},
  author={Edmund J. Sybertz and Thomas Baum and Kathryn Pula and Steve Nelson and E Eynon and C S Sabin},
  journal={Journal of Cardiovascular Pharmacology},
  year={1982},
  volume={4},
  pages={749–758}
}
  • E. Sybertz, T. Baum, C. Sabin
  • Published 1 September 1982
  • Medicine, Chemistry, Biology
  • Journal of Cardiovascular Pharmacology
Summary Several new β-adrenoceptor antagonists (sulfinalol, MK 761, and prizidilol) have been reported to possess direct vasodilator activity in addition to blocking β-receptors. The mechanism of the hypotensive and vasodilator actions of these agents was examined and compared to that of pindolol and hydralazine. Intraarterial injection of each agent increased blood flow in the sympathetically denervated hindlimb of anesthetized dogs. Doses increasing flow by 50 ml/min (ED50) were 0.48, 0.24… 
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  • Chemistry, Medicine
    Clinical and experimental pharmacology & physiology
  • 1986
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  • Biology, Medicine
    British journal of clinical pharmacology
  • 1990
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