Studies on the Mechanism of Toxicity of DDT and Polychlorinated Biphenyls: Disruption of Osmoregulation in Marine Fish

@article{Kinter1972StudiesOT,
  title={Studies on the Mechanism of Toxicity of DDT and Polychlorinated Biphenyls: Disruption of Osmoregulation in Marine Fish},
  author={William B. Kinter and Louise S. Merkens and R. H. Janicki and Anthony Guarino},
  journal={Environmental Health Perspectives},
  year={1972},
  volume={1},
  pages={169 - 173}
}
In 1970 studies were initiated at the Mount Desert Island Biological Laboratory to explore mechanisms of toxicity underlying the high sensitivity of bony fish, teleosts, to organochlorine pollutants. The starting point was several reports that DDT [1,1,1-trichloro-2, 2-bis (p-chlorophenyl) ethane] inhibited Na,K-ATPase (Na+, K+-activated adenosine triphosphatase), as well as the knowledge that this enzyme appears to play a central role in osmoregulation by marine teleosts. In the face of a… CONTINUE READING
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