Studies on the Active Form of Oral Gefarnate

@article{Kajiwara1980StudiesOT,
  title={Studies on the Active Form of Oral Gefarnate},
  author={Yoshio Kajiwara and Yokoi Shigeru and Hatsushi Shimomura and Kizaki Tokio and Toshima Yoichi and Seiichiro Yoshida and Ryuta Ito},
  journal={Rinsho Yakuri\/japanese Journal of Clinical Pharmacology and Therapeutics},
  year={1980},
  volume={11},
  pages={263-269}
}
  • Y. Kajiwara, Yokoi Shigeru, R. Ito
  • Published 30 October 1980
  • Biology, Chemistry
  • Rinsho Yakuri\/japanese Journal of Clinical Pharmacology and Therapeutics
This paper describes a possibility that a metabolite of orally administered gefarnate (GF), an antiulcerative agent, is an acting substance, instead of GF.When GF was orally administered in rabbits or rats, its metabolites, farnesylacetic acid (FAA), geraniol etc. were clearly detected in portal or lymphatic flow, while mother compound GF was not detectable. FAA revealed about 100 times potent increase in the O2 consumption of mitochondria of rat liver than that of GF. When FAA (4 mg/kg) was… 
1 Citations
Synthetic analogs of phytanic acid and their effect on human hepatic cholesterol esterase in vitro
TLDR
Achiral (E,E)-5,9,13-trimethyltetradeca-4,8,12-trienoic (farnesylacetic) acid, a low-toxicity antiulcerative substance, also significantly accelerates the HLCE-catalyzed hydrolysis of cholesteryl palmitate.

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