Studies on tableting properties of lactose

@article{Vromans1985StudiesOT,
  title={Studies on tableting properties of lactose},
  author={Herman Vromans and Albertus Hendrikus de Boer and Gerad Klaas Bolhuis and Coenraad F. Lerk and Klaas Dani{\"e}l Kussendrager and Hubert Bosch},
  journal={Pharmaceutisch Weekblad},
  year={1985},
  volume={7},
  pages={186-193}
}
Lactose is available in several crystalline forms, which differ in binding properties. A new method of estimating the fragmentation propensity was applied to investigate the consolidation and compaction behaviour of this excipient for direct compression. Mercury porosimetry was used to demonstrate that crystalline lactose fragments during compaction. Tablet strength was found to be dependent on the degree of fragmentation only. This finding indicates that the nature of the actual binding must… CONTINUE READING
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