Studies on ribosome structure and interactions near the m62Am62A sequence.

@article{Thammana1978StudiesOR,
  title={Studies on ribosome structure and interactions near the m62Am62A sequence.},
  author={Pallaiah Thammana and Charles R. Cantor},
  journal={Nucleic acids research},
  year={1978},
  volume={5 3},
  pages={805-23}
}
Antibodies raised against N6, N6-dimethyl adenosine were used to study the environment and role of the m62Am62A sequences in the E. coli ribosome. It is observed that this sequence is exposed on the surface of isolated 30S subunits, but becomes inaccessible for IgG interaction upon heat activation. The m62Am62A sequence is also inaccessible for IgG interaction in 70S ribosomes or 30S subunits immediately after dissociation of 70S particles. The presence of IgGs results in a significant… CONTINUE READING