Studies on rat renal cortical cell kallikrein. II. Identification of kallikrein as an ecto-enzyme.

@article{Chao1979StudiesOR,
  title={Studies on rat renal cortical cell kallikrein. II. Identification of kallikrein as an ecto-enzyme.},
  author={Julie Chao and Harry S. Margolius},
  journal={Biochimica et biophysica acta},
  year={1979},
  volume={570 2},
  pages={330-40}
}
Suspensions of viable renal cortical cells hydrolyzed a synthetic ester substrate (alpha-N-tosyl-L-arginine methyl ester, Tos-Arg-OMe) and generated kinins from a kininogen substrate. This kallikrein-like esterase activity increased linearly with cell number, or time of exposure to substrate. No radiolabelled substrate or product was found within the cells. Most of the activity appeared to be on cell surfaces as supernatant media had less than 20% of the Tos-Arg-OMe esterase activity on the… CONTINUE READING

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