Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate

@article{Huggins1972StudiesOP,
  title={Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate},
  author={Charles B. Huggins and Clarence V. Hodges},
  journal={CA: A Cancer Journal for Clinicians},
  year={1972},
  volume={22}
}
Carcinoma of the prostate gland is peculiarly favorable for endocrine investigation since frequent serial observations of the activity of phosphatases in serum were found to provide objective indices of activity of the neo/~i~m when the enzymes were increased in amount above normal. In the present paper data are given for the values of serum phosphatases in carcinoma of the prostate and in normal men. We shall demonstrate that the acid phosphatase of serum is reduced in metastatic carcinoma of… 
Studies on prostatic cancer I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate by Charles Huggins and Clarence V. Hodges.
TLDR
The goals of Huggins and Hodges were to present the values of serum phosphatases in normal men and patients with carcinoma of the prostate and to demonstrate that the serum levels of acid phosphatase were reduced in metastatic PCa by decreasing the activity of androgens and increased after androgens injections.
Endocrine Aspects and Steroid Receptors in Prostatic Carcinoma
TLDR
In vitro studies of steroid metabolism and steroid receptors in benign prostatic hyperplasia (BPH) and in prostatic cancer (PC), together with studies on the hormonal status of patients, have shed some light on certain aspects of these diseases.
Hormonal therapy of prostate cancer.
  • F. Labrie
  • Medicine, Biology
    Progress in brain research
  • 2010
Biochemical endocrinology of prostatic tumors.
  • K. Voigt, M. Krieg
  • Medicine, Biology
    Current topics in experimental endocrinology
  • 1978
Combination therapy in stage C and D prostatic cancer: rationale and five-year clinical experience
TLDR
Clinical studies in previously untreated stage D2 and C prostate cancer patients with the combination therapy using the LHRH agonist [D-Trp6, des Gly NH210] L HRH ethylamide and the antiandrogen Flutamide showed a significant increase in patients with a complete response, as compared with studies limited to the removal or blockade of testicular androgens.
[A study of correlations between therapeutic efficacy of anti-androgen therapy in prostatic cancer and androgen receptor content of prostatic cancer tissue].
TLDR
The results indicate the possible usefulness of androgen receptor contained in prostatic cancer tissue as an index for the selection of appropriate initial therapy for prostaticcancer.
Treatment of prostate cancer with gonadotropin-releasing hormone agonists.
TLDR
In order to inhibit the action of androgens of both testicular and adrenal origin, GnRH agonists have been administered in association with the pure antiandrogen Flutamide in patients having clinical stage D2 (bone metastases) prostate cancer.
[Immunohistochemical study of androgen receptor in adenocarcinoma of the human prostatic cancer].
TLDR
The results suggest that the detection of AR with immunohistochemical study is useful for estimating the prognosis of the patients undergone anti-androgen therapy.
Endocrine treatment of prostate cancer.
TLDR
Integration of endocrine treatment at this earlier phase in the pathogenesis of prostate cancer will substantially alter the treatment strategy in relation to long-term benefit with regard to survival, associated side effects, and costs.
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TLDR
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red-violet or violet, beginning at once on addition of the BLOOD PHOSPHATASE AND THE VAN DEN BERGH reagent, the whole process taking several minutes and REACTION IN THE DIFFERENTIATION OF sometimes
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