Studies on propafenone-type modulators of multidrug-resistance IV1): synthesis and pharmacological activity of 5-hydroxy and 5-benzyloxy derivatives.

Abstract

A series of 5-hydroxy and 5-benzyloxy analogs of the antiarrhythmic and multidrug resistance (MDR) modulating drug propafenone was synthesized and the MDR-modulating activity of the compounds was evaluated using a daunomycin efflux assay system. The key step of the synthesis is the selective reduction of the double bond in 1 without cleavage of the benzyl… (More)

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@article{Chiba1997StudiesOP, title={Studies on propafenone-type modulators of multidrug-resistance IV1): synthesis and pharmacological activity of 5-hydroxy and 5-benzyloxy derivatives.}, author={Peter Chiba and B L Tell and W. J{\"a}ger and Eric Richter and Manuela Hitzler and Gerhard F. Ecker}, journal={Archiv der Pharmazie}, year={1997}, volume={330 11}, pages={343-7} }