Studies on pituitary prolactin. 39. Reaction of the ovine hormone with hydrogen peroxide.

@article{Houghten1976StudiesOP,
  title={Studies on pituitary prolactin. 39. Reaction of the ovine hormone with hydrogen peroxide.},
  author={Richard A. Houghten and Choh Hao Li},
  journal={Biochimica et biophysica acta},
  year={1976},
  volume={439 1},
  pages={
          240-9
        }
}
Three methionine-modified derivatives of ovine prolactin have been prepared: two by oxidation of the methionines by H2O2 to sulfoxide (partial and complete), and the third by complete alkylation of the metionines with iodoacetic acid to the carboxymethyl sulfonium salts. The derivatives were characterized by exclusion chromatography, amino acid composition, circular dichroism spectra, relative rates of digestion by trypsin, and biological activity. Partially oxidized prolactin, having four of… CONTINUE READING