• Corpus ID: 33377789

Studies on osteoporosis IV. Effect of benzo[b]thiophene-2- and dibenzothiophene-4-carboxylic acid on heparin accelerated osteoporosis.

@article{Robin1980StudiesOO,
  title={Studies on osteoporosis IV. Effect of benzo[b]thiophene-2- and dibenzothiophene-4-carboxylic acid on heparin accelerated osteoporosis.},
  author={J. C. Robin and S. D. Sharma and K Francis and Myra Rosenstein and Robert H. Moore and J{\'u}lius Vida and C C Thomas and Julian L. Ambrus},
  journal={Journal of medicine},
  year={1980},
  volume={11 1},
  pages={
          15-27
        }
}
Total skeletal calcium was determined in female mice with the aid of whole body neutron activation analysis. Three months treatment with heaprin produced significant osteoporosis in C3-H/St(Ha) mice but not in C57/BL6(J) mice. This was more pronounced in the younger (5-8 months) than in the older (15-18 months) animals. Two 2-thiophene carboxylic acid derivatives showed significant osteoporosis preventive activity. 

The effect of thionaphthene-2-carboxylic acid (TNCA) on bone structure in the rat: a histomorphometric study.

This study constitutes the first of its kind to demonstrate the in-vivo effect of TNCA on the bones of rats and found it was stimulatory at the low dosage and inhibitory at the high dose.

Benzo(B)Thiophene-2-Carboxylic acid: Calcium uptake and cyclic AMP production in isolated bone cells

BL-5583 inhibited spontaneous as well as A23187 and PTH-induced bone resorption in tissue culture and induced a transient decrease in calcium uptake in skin cells isolated from fetal rats by collagenase digestion, suggesting a lack of tissue specificity for this compound.

Effects of thionapthene 2-carboxylic acid and related compounds on bone resorption in organ culture

TNCA had a powerful inhibitory effect when it was added to bones that had previously escaped from CT, and this suggests that TNCA will be most effective under conditions of accelerated bone resorption when an inhibiting effect is most desirable.