Studies on new cyclic imides obtained from aminophenazone with analgesic properties. Potent effects of a 3,4-dichloromaleimide derivative.

@article{Campos2002StudiesON,
  title={Studies on new cyclic imides obtained from aminophenazone with analgesic properties. Potent effects of a 3,4-dichloromaleimide derivative.},
  author={F{\'a}tima de Campos and Rog{\'e}rio Nappi Corr{\^e}a and M{\'a}rcia Maria de de Souza and Rosendo Augusto Yunes and Ricardo Jos{\'e} Nunes and Valdir Cechinel-Filho},
  journal={Arzneimittel-Forschung},
  year={2002},
  volume={52 6},
  pages={455-61}
}
This paper describes the synthesis of new cyclic imides obtained by reaction with aminophenazone (CAS 58-15-1, 4-aminoantipyrine) and different anhydrides with further cyclization with acetic acid under reflux. Their structures were confirmed by spectral data (IR and NMR) and elemental analysis. The analgesic activity of the synthesized compounds was investigated initially with the writhing test in mice and the most promising compound, a 3,4-dichloromaleimide derivative (3), was analyzed using… CONTINUE READING