Studies on neurosteroids XXV. Influence of a 5alpha-reductase inhibitor, finasteride, on rat brain neurosteroid levels and metabolism.

@article{Mukai2008StudiesON,
  title={Studies on neurosteroids XXV. Influence of a 5alpha-reductase inhibitor, finasteride, on rat brain neurosteroid levels and metabolism.},
  author={Yoshiyuki Mukai and T. Higashi and Yukiko Nagura and K. Shimada},
  journal={Biological & pharmaceutical bulletin},
  year={2008},
  volume={31 9},
  pages={
          1646-50
        }
}
  • Yoshiyuki Mukai, T. Higashi, +1 author K. Shimada
  • Published 2008
  • Chemistry, Medicine
  • Biological & pharmaceutical bulletin
  • In this study, we examined the influence of finasteride (FIN), a 5alpha-reductase inhibitor, on the brain levels and metabolism of neurosteroids [allopregnanolone (AP), 3alpha-dihydroprogesterone (3alpha-DHP), progesterone (PROG), 20alpha-dihydroprogesterone and 11-deoxycorticosterone (DOC)] in rats exposed to immobilization stress. For this purpose, the sensitive, reproducible and accurate liquid chromatography-electrospray ionization-tandem mass spectrometric (LC-ESI-MS/MS) methods that… CONTINUE READING
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