Studies on metabolic activation of vinyl chloride in Drosophila melanogaster after pretreatment with phenobarbital and polychlorinated biphenyls.

@article{Magnusson1979StudiesOM,
  title={Studies on metabolic activation of vinyl chloride in Drosophila melanogaster after pretreatment with phenobarbital and polychlorinated biphenyls.},
  author={Jan Magnusson and Inger Porsch H{\"a}llstr{\"o}m and Claes Ramel},
  journal={Chemico-biological interactions},
  year={1979},
  volume={24 3},
  pages={287-98}
}
It is known that vinyl chloride is metabolized by the mixed function oxygenase system in the liver to reactive mutagenic and carcinogenic metabolites. This metabolic activation was studied in Drosophila melanogaster by measuring the uptake of 14C from labelled vinyl chloride in different strains and with different pretreatments with phenobarbital and polychlorinated biphenyl (PCB) Clophen A50), well known inducers of cytochrome P-450. In accordance with previously obtained data on vinyl… CONTINUE READING

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