Studies on lung N-methyltransferases, a pharmacological approach

@article{Pendleton2004StudiesOL,
  title={Studies on lung N-methyltransferases, a pharmacological approach},
  author={Robert G. Pendleton and George W. Gessner and John L. Sawyer},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={313},
  pages={263-268}
}
SummaryPhenylethanolamine N-methyltransferase (PNMT) was identified as the primary, high affinity N-methylating enzyme for phenylethanolamine (PEA) in rat, dog and Rhesus monkey lung. Human and rabbit lung, however, do not contain this enzyme but possess a more non-specific or general N-methyltransferase with a relatively low affinity for PEA and for which β-phenethylamine (β-PE) is also a substrate. The former but not the latter enzyme is markedly inhibited by micromolar concentrations of the… Expand
2 Citations
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