Studies on lung N-methyltransferases, a pharmacological approach

  title={Studies on lung N-methyltransferases, a pharmacological approach},
  author={Robert G. Pendleton and George W. Gessner and John L. Sawyer},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
SummaryPhenylethanolamine N-methyltransferase (PNMT) was identified as the primary, high affinity N-methylating enzyme for phenylethanolamine (PEA) in rat, dog and Rhesus monkey lung. Human and rabbit lung, however, do not contain this enzyme but possess a more non-specific or general N-methyltransferase with a relatively low affinity for PEA and for which β-phenethylamine (β-PE) is also a substrate. The former but not the latter enzyme is markedly inhibited by micromolar concentrations of the… 
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Studies on adrenal phenylethanolamine N- methyltransferase (PNMT) with S K & F 64139, a selective inhibitor.

Evidence for in vivo phenylethanolamine N-methyltransferase inhibitory activity was that the drug markedly inhibited the conversion of a tracer dose of 3H-norepinephrine to3H-epinephrine in the rat adrenal gland after unit oral doses as low as 5 mg/kg.

Studies on the characterization and inhibition of rat brain phenylethanolamine N-methyltransferase

SummaryThe existence of phenylethanolamine N-methyltransferase (PNMT) activity in the rat brain and spinal cord was confirmed using both substrate specificity and selective inhibitors of the adrenal

Studies on the distribution of phenylethanolamine N-methyltransferase and epinephrine in the rat.

The data indicate that although the adrenal is the principal tissue source of epinephrine and PNMT in the rat, small amounts of both substances are present in several body organs.

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The serotonin methylating enzyme can N-methylate a variety of normally occurring compounds such as dopamine, normetanephrine, metanephine, epinephrine, tyramine, and octopamine as well as a varietyof foreign compounds suchAs ephedrine, amphetamine, aniline, normorphine,normeperidine and nornicotine.

Statistical Methods

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    Springer Theses
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The three standard multivariate methods, PCA (Principal Component Analysis), Factor Analysis, and CCA (Canonical Correlations Analysis) will be reviewed and their connection with divergence minimization discussed.

Statistical estimation in enzyme kinetics

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