Studies on lipid peroxidation in the rat brain

  title={Studies on lipid peroxidation in the rat brain},
  author={Maurizio Cini and Ruggero G. Fariello and Andrea Bianchetti and Alessandra Moretti},
  journal={Neurochemical Research},
The aim of this study was to set up a simple procedure for assessing lipid peroxidation (L.P.) and testing the activity of antioxidant compounds. L. P. was determined in rat brain homogenates by measuring the endogenous and stimulated accumulation of malonaldehyde (MDA). MDA was assayed by an HPLC method. Homogenates spontaneously formed appreciable amounts of MDA. The addition of increasing concentrations of FeCl2 resulted in a linear accumulation of MDA, up to 16.6-fold at 50 μM. An organic… CONTINUE READING


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