Studies on lipid biosynthesis and cholesterol content of liver and serum lipoproteins in rats fed various phthalate esters

@article{Bell1978StudiesOL,
  title={Studies on lipid biosynthesis and cholesterol content of liver and serum lipoproteins in rats fed various phthalate esters},
  author={Frank P. Bell and Carol S. Patt and B E Brundage and Peter J. Gillies and William A. Phillips},
  journal={Lipids},
  year={1978},
  volume={13},
  pages={66-74}
}
The effect of various phthalate ester plasticizers on lipid metabolism in rats was studied in vivo and in vitro. Di-2-ethylhexyl phthalate (DEHP) and di-n-butyl phthalate (DBP) inhibited (30–70%) hepatic sterologenesis from14C-acetate and14C-mevalonate in liver minces from rats fed the phthalates at a level of 2.5 mmoles/100 g of chow diet for 21 days; inhibition of14C-acetate incorporation into phospholipids, triglycerides, and steryl esters was reduced (35–70%) by DEHP and DBP feeding. In… CONTINUE READING
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