Corpus ID: 25756780

Studies on interactions of dTK-HSV mutants with neurons in vitro.

  title={Studies on interactions of dTK-HSV mutants with neurons in vitro.},
  author={V Veerisetty and Glenn A. Gentry and I. K. Veerisetty and Edward R. North},
  journal={Acta virologica},
  volume={30 1},
  • V Veerisetty, Glenn A. Gentry, +1 author Edward R. North
  • Published in Acta virologica 1986
  • Biology, Medicine
  • Thymidine kinase negative (dTK-) mutants of herpes simplex virus type 1 (HSV-1) multiplied well in rat brain glioma cells. A proportion (less than 1%) of glioma cells survived the infection with HSV and were designated "survivor" glioma cells. Survivor cells of dTK- mutant virus infection ceased to produce infectious virus after two passages and were highly resistant to both HSV-1 and HSV-2 but not to vesicular stomatitis virus (VSV). Flow cytometric studies indicated morphological differences… CONTINUE READING

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