Studies on interactions between functional foods or dietary supplements and medicines. I. Effects of Ginkgo biloba leaf extract on the pharmacokinetics of diltiazem in rats.

@article{Ohnishi2003StudiesOI,
  title={Studies on interactions between functional foods or dietary supplements and medicines. I. Effects of Ginkgo biloba leaf extract on the pharmacokinetics of diltiazem in rats.},
  author={N. Ohnishi and M. Kusuhara and M. Yoshioka and K. Kuroda and Akihiro Soga and F. Nishikawa and Tomokazu Koishi and M. Nakagawa and S. Hori and T. Matsumoto and M. Yamashita and Shunsaku Ohta and K. Takara and T. Yokoyama},
  journal={Biological & pharmaceutical bulletin},
  year={2003},
  volume={26 9},
  pages={
          1315-20
        }
}
  • N. Ohnishi, M. Kusuhara, +11 authors T. Yokoyama
  • Published 2003
  • Chemistry, Medicine
  • Biological & pharmaceutical bulletin
  • The effects of Ginkgo biloba leaf extract (GBE), one of the most widely used herbal dietary supplements in Japan, on the pharmacokinetics of diltiazem (DTZ), a typical probe of cytochrome P450 (CYP) 3A, were examined in rats. The simultaneous addition of GBE to small intestine and liver microsomes inhibited the formation of N-demethyl DTZ (MA), an active metabolite of DTZ produced by CYP3A, in a concentration-dependent manner, with an IC(50) of about 50 and 182 microg/ml, respectively. This… CONTINUE READING
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