Studies on interactions between functional foods or dietary supplements and medicines. I. Effects of Ginkgo biloba leaf extract on the pharmacokinetics of diltiazem in rats.

Abstract

The effects of Ginkgo biloba leaf extract (GBE), one of the most widely used herbal dietary supplements in Japan, on the pharmacokinetics of diltiazem (DTZ), a typical probe of cytochrome P450 (CYP) 3A, were examined in rats. The simultaneous addition of GBE to small intestine and liver microsomes inhibited the formation of N-demethyl DTZ (MA), an active… (More)

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@article{Ohnishi2003StudiesOI, title={Studies on interactions between functional foods or dietary supplements and medicines. I. Effects of Ginkgo biloba leaf extract on the pharmacokinetics of diltiazem in rats.}, author={Noriaki Ohnishi and Mayako Kusuhara and Mutsunobu Yoshioka and Kazuo Kuroda and Akihiro Soga and Fumi Nishikawa and Tomokazu Koishi and Masato Nakagawa and Satoshi Hori and Tsuyoshi Matsumoto and Masayuki Yamashita and Shunsaku Ohta and K. Takara and Teruyoshi Yokoyama}, journal={Biological & pharmaceutical bulletin}, year={2003}, volume={26 9}, pages={1315-20} }