Studies on interaction of norbixin with DNA: multispectroscopic and in silico analysis.

@article{Anantharaman2015StudiesOI,
  title={Studies on interaction of norbixin with DNA: multispectroscopic and in silico analysis.},
  author={Amrita Anantharaman and Rajendra Rao Priya and Hridya Hemachandran and Akella Sivaramakrishna and Subramanian Babu and R Siva},
  journal={Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy},
  year={2015},
  volume={144},
  pages={163-9}
}
The interaction of food colorant norbixin with calf thymus DNA (CTDNA) was investigated through UV-Visible spectroscopy, Fourier Transform Infrared (FTIR), Circular Dichroism (CD), Nuclear Magnetic Resonance (NMR), DNA melting studies, electrophoretic analysis, histological staining technique and molecular docking studies. The results indicated that norbixin interacted with CTDNA by partial intercalation mode. The binding constant (K) of norbixin with CTDNA was calculated to be 5.08×10(5) Mol… CONTINUE READING