Studies on immunity to Haemophilus pleuropneumoniae infections in mice.

@article{Sebunya1982StudiesOI,
  title={Studies on immunity to Haemophilus pleuropneumoniae infections in mice.},
  author={T N Sebunya and J. R. Saunders},
  journal={American journal of veterinary research},
  year={1982},
  volume={43 10},
  pages={1793-8}
}
A murine model of experimentally induced Haemophilus pleuropneumoniae respiratory tract infections was developed and used to evaluate the efficacy of bacterins. Various doses of 3 H pleuropneumoniae strains (serotype 1 and 5) were administered intranasally (IN) to groups of anesthetized Swiss White mice. The accumulated mortality per group at 5 days after they were inoculated was used to calculate the median lethal dose (LD50), which ranged between 1.4 x 10(6) and 5.4 x 10(7) bacteria. There… CONTINUE READING