Studies on human porin XXII: cell membrane integrated human porin channels are involved in regulatory volume decrease (RVD) of HeLa cells.

@article{Thinnes2000StudiesOH,
  title={Studies on human porin XXII: cell membrane integrated human porin channels are involved in regulatory volume decrease (RVD) of HeLa cells.},
  author={Friedrich P. Thinnes and K.-H. Hellmann and Thea Hellmann and Rolf Merker and U Brockhaus-Pruchniewicz and Christian Schwarzer and G{\"o}tz Walter and Hilde G{\"o}tz and Norbert Hilschmann},
  journal={Molecular genetics and metabolism},
  year={2000},
  volume={69 4},
  pages={331-7}
}
Cell volume regulation receives increasing attention not only as the basis of regulatory volume increase or regulatory volume decrease (RVD) of cells in surroundings of changing osmolarity, but also appears to be relevant in cell proliferation, differentiation, and apoptosis. A central event in RVD is the opening of a volume-sensitive chloride/anion channel(s), and blocking this pathway would abolish RVD. This is shown here with monoclonal mouse anti-human type-1 porin antibodies, proving that… CONTINUE READING

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