Studies on histone organization in the nucleosome using formaldehyde as a reversible cross-linking agent

@article{Jackson1978StudiesOH,
  title={Studies on histone organization in the nucleosome using formaldehyde as a reversible cross-linking agent},
  author={V. Jackson},
  journal={Cell},
  year={1978},
  volume={15},
  pages={945-954}
}
  • V. Jackson
  • Published 1978
  • Biology, Medicine
  • Cell
  • A new procedure is described which allows selective reversal of formaldehyde cross-linking in both histone-histone and histone-DNA of nuclei isolated from calf thymus. All ten possible dimers of the four non-H1 histones, H3, H2B, H2A and H4, are observed, the major dimers being H3-H3, H3-H2A, H2B-H2A, H2a-H2A and two separate dimers of H2B-H4. Although oligomers of the non-H1 histones are formed by prolonged treatment with this reagent, 50% of the histones continue to remain resistant to cross… CONTINUE READING

    Topics from this paper.

    Exchange of histones H1, H2A, and H2B in vivo.
    • 83

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