• Corpus ID: 54821476

Studies on factors modulating glucose homeostasis in healthy and diabetic rats

@inproceedings{Yassin2011StudiesOF,
  title={Studies on factors modulating glucose homeostasis in healthy and diabetic rats},
  author={Kamal eldin Eltayeb Yassin},
  year={2011}
}
  • K. Yassin
  • Published 29 September 2011
  • Biology, Medicine
Glucose is the most common substrate for energy metabolism. Despite the varying demands for glucose, the body needs to regulate its internal environment and maintain a constant and stable condition. Glucose homeostasis requires harmonized interaction between several tissues, achieving equilibrium between glucose output and uptake. In this thesis, we aimed to investigate factors modulating glucose homeostasis in a rat model of type 2 diabetes, the Goto-Kakizaki (GK) rat. In addition, we… 
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References

SHOWING 1-10 OF 169 REFERENCES
Insulin resistance in the GK rat: decreased receptor number but normal kinase activity in liver.
TLDR
In vivo insulin action was assessed in 8-wk-old GK females at basal and submaximal (euglycemic clamp) insulin levels and peripheral insulin resistance was installed at 8 wk of age, demonstrating liver insulin resistance.
Role of Liver in Pathophysiology of NIDDM
TLDR
Preliminary data suggest that in the postprandial state increased gluconeogenesis represents the primary mechanism responsible for impaired suppression of hepatic glucose production in non-insulin-dependent diabetes mellitus.
Splanchnic regulation of glucose production.
TLDR
The liver plays a key role for the maintenance of blood glucose homeostasis under widely changing physiological conditions and gluconeogenesis becomes gradually more important in keeping with falling insulin and rising glucagon levels during prolonged exercise.
Insulin stimulation of glucose uptake in skeletal muscles and adipose tissues in vivo is NO dependent.
TLDR
The hypothesis that the action of insulin to augment glucose uptake by skeletal muscles and other peripheral insulin-sensitive tissues in vivo is NO dependent is supported.
Insulin stimulation of glucose uptake in skeletal muscles and adipose tissues in vivo is NO dependent.
TLDR
The hypothesis that the action of insulin to augment glucose uptake by skeletal muscles and other peripheral insulin-sensitive tissues in vivo is NO dependent is supported.
The role of islet secretory function in the development of diabetes in the GK Wistar rat
TLDR
It is suggested that abnormalities in islet function are present in 8-week-old diabetic animals although these do not seriously impair glucose-stimulated insulin release from isolated islets, and that deterioration of the secretory response is the consequence of some factor associated with the diabetic condition.
Signaling pathways in insulin action: molecular targets of insulin resistance.
TLDR
The regulation of glucose transport as the rate-limiting step in glucose utilization and storage is focused on.
Current strategies for the inhibition of hepatic glucose production in type 2 diabetes.
TLDR
Currently available therapeutics which target insulin resistance in the liver are focused on and other hepatic targets are being considered which may lead to alternative strategies for the treatment of diabetes.
A Defective Stimulus-Secretion Coupling Rather Than Glucotoxicity Mediates the Impaired Insulin Secretion in the Mildly Diabetic F1 Hybrids of GK-Wistar Rats
TLDR
In hybrid rats, the insulin response to glucose is impaired already at neonatal age and this impairment was not restored by long-term maintenance of the hybrid islets in a normoglycemic environment, whereas the arginine effect was intact.
Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus.
TLDR
The results emphasize the importance of the peripheral tissues in the disposal of infused glucose and indicate that muscle is the most important site of the insulin resistance in NIDD.
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