Studies on drug release kinetics from ibuprofen-carbomer hydrophilic matrix tablets: influence of co-excipients on release rate of the drug.

@article{Khan1999StudiesOD,
  title={Studies on drug release kinetics from ibuprofen-carbomer hydrophilic matrix tablets: influence of co-excipients on release rate of the drug.},
  author={Gul Majid Khan and Jia Bi Zhu},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={1999},
  volume={57 2},
  pages={197-203}
}
Controlled-release (CR) matrix tablets of ibuprofen (IBF) and Carbopol(R) 934P, and blended mixture of Carbopol(R) 934P and 971P resins, at different drug to polymers ratios, were prepared by the direct compression method. The investigation focuses on the influence of the proportion of the matrix material, and several co-excipients (lactose, microcrystalline cellulose (MCC), and starch) on the mechanism and release rate of the drug from the tablets. In vitro drug release in pH 7.2 phosphate… CONTINUE READING

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