Studies on drug absorption from oral cavity. II. Influence of the unstirred water layer on absorption from hamster cheek pouch in vitro and in vivo.

@article{Kurosaki1987StudiesOD,
  title={Studies on drug absorption from oral cavity. II. Influence of the unstirred water layer on absorption from hamster cheek pouch in vitro and in vivo.},
  author={Yuji Kurosaki and S Hisaichi and Chieko Hamada and Taiji Nakayama and T. D. Kimura},
  journal={Journal of pharmacobio-dynamics},
  year={1987},
  volume={10 4},
  pages={180-7}
}
The influence of the unstirred water layer (UWL) adjacent to the membrane surface of the hamster cheek pouch on absorption was studied in vitro and in vivo. The tissue uptake rate of 14C-laurylalcohol was determined in vitro and the value of the effective resistance of UWL (RW) was calculated. RW values were reduced by increasing the stirring rate of the mucosal solution. In vitro permeation of 14C-benzoic acid into the serosal compartment was also increased in the well-stirred condition. Thus… CONTINUE READING