Studies on disease-modifying antirheumatic drugs: synthesis of novel quinoline and quinazoline derivatives and their anti-inflammatory effect.

@article{Baba1996StudiesOD,
  title={Studies on disease-modifying antirheumatic drugs: synthesis of novel quinoline and quinazoline derivatives and their anti-inflammatory effect.},
  author={A. Ramesha Baba and Noriko Kawamura and Haruhiko Makino and Yuko Ohta and Shigehisa Taketomi and Takashi Sohda},
  journal={Journal of medicinal chemistry},
  year={1996},
  volume={39 26},
  pages={5176-82}
}
In the course of our study aimed at developing new types of DMARDs (disease-modifying antirheumatic drugs), we found that quinoline derivative 1a had a potent anti-inflammatory effect in an adjuvant arthritis (AA) rat model, starting from the potent bone resorption inhibitors justicidins as the lead compounds. Further modification of 1a was performed, and various quinoline and quinazoline derivatives having a heteroaryl moiety on the alkyl side chain at the 2-position of the skeleton were… CONTINUE READING

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