Studies on deoxyribonucleoproteins. IX. Subfractions of deoxyribonucleoproteins from rat and mouse liver.

@article{Harbers1975StudiesOD,
  title={Studies on deoxyribonucleoproteins. IX. Subfractions of deoxyribonucleoproteins from rat and mouse liver.},
  author={E Harbers and H. Hollandt and C. Eilers-K{\"o}nig and Rainer Schneider and C Struttmann and Peter Warnecke},
  journal={Hoppe-Seyler's Zeitschrift fur physiologische Chemie},
  year={1975},
  volume={356 6},
  pages={671-5}
}
By carrier-free continuous electrophoresis, deoxyribonucleoprotein from rat and mouse liver could be separated into two subfractions. The more anodic fraction (DNP I), comprising 5 - 8 per cent of the total, contains fewer proteins (two types of histones only). [3H]Cyclophosphamide caused in vivo a 2.5 times higher alkylation of the DNA in in DNP I than of the DNA in DNP II. These and additional results led to the suggestion of a structural model with DNP I as a spacer in the… CONTINUE READING

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