Studies on coumarins and coumarin-related compounds to determine their therapeutic role in the treatment of cancer.

  title={Studies on coumarins and coumarin-related compounds to determine their therapeutic role in the treatment of cancer.},
  author={A. Lacy and R. O'Kennedy},
  journal={Current pharmaceutical design},
  volume={10 30},
The Benzopyrones are a group of compounds whose members include coumarins and flavonoids. [...] Key Method The most recent work involves two cell-lines, MCF-7 a breast carcinoma and A549 a lung carcinoma. Microtitre assays were performed along with real-time analysis of cell viability using a biosensor called the Cytosensor microphysiometer. These studies suggest that both genistein and esculetin exerted the most potent inhibitory effect on cell growth in comparison to the other two compounds.Expand
461 Citations

Paper Mentions

Interventional Clinical Trial
Open-label studies, anecdotal reports, and in vitro scientific research indicate that 4-methylumbelliferone (active ingredient of the dietary supplement Heparvit®) may prevent and… Expand
ConditionsChronic Hepatitis B, Chronic Hepatitis C
An insight into the therapeutic applications of coumarin compounds and their mechanisms of action.
  • Sourbh Garg, J. Gupta, S. Sharma, D. Sahu
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2020
  • 3
Studying plant-derived coumarins for their pharmacological and therapeutic properties as potential anticancer drugs
  • I. Kostova
  • Medicine
  • Expert opinion on drug discovery
  • 2007
  • 35
A review of coumarin derivatives in pharmacotherapy of breast cancer.
  • 322
Coumarins in Food and Methods of Their Determination
  • 5
  • Highly Influenced
  • PDF
Coumarin derivatives: an updated patent review (2012 – 2014)
  • 46
Synthesis of New 4- methyl coumarin derivatives
  • 2
Transport of the Coumarin Metabolite 7-Hydroxycoumarin Glucuronide Is Mediated via Multidrug Resistance-Associated Proteins 3 and 4
  • 16
  • PDF
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds
  • 96
  • PDF


Studies on the mode of action of coumarins (coumarin, 6-hydroxycoumarin, 7-hydroxycoumarin & esculetin) at a cellular level
  • 11
  • Highly Influential
Biological Screening of Plant Coumarins
  • 60
  • PDF
Antitumor-activities of coumarin, 7-hydroxy-coumarin and its glucuronide in several human tumor cell lines.
  • 125
Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment.
  • B. Lake
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1999
  • 393
  • Highly Influential
Structure -Cytotoxicity Relationships of a Series of Natural and Semi-Synthetic Simple Coumarins as Assessed in Two Human Tumour Cell Lines
  • 39
  • PDF
CYP2A6: a human coumarin 7-hydroxylase.
  • 231
  • Highly Influential
Metabolism of Coumarin in Man
  • 135
The effects of coumarin and suramin on the growth of malignant renal and prostatic cell lines
  • 47
Development of novel analytical methods to study the metabolism of coumarin
  • 6
  • PDF