Studies on coumarin anticoagulant drugs. Initiation of warfarin therapy without a loading dose.

@article{OReilly1968StudiesOC,
  title={Studies on coumarin anticoagulant drugs. Initiation of warfarin therapy without a loading dose.},
  author={Robert A O'Reilly and P M Aggeler},
  journal={Circulation},
  year={1968},
  volume={38 1},
  pages={
          169-77
        }
}
Thirty normal subjects were given a single loading dose of warfarin sodium, 1.5 mg/kg of body weight. The drug was metabolized slowly (mean biological half-life, 47 hr) and showed a prolonged biological effect (over 6 days). In two separate experiments no loading dose was given; instead, daily doses of 15 mg and 10 mg were administered to 15 of the subjects. The prothrombin complex responses were compared with those obtained in the same subjects after the large loading dose. The mean time in… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 15 references

Disap - pearance rates of coagulation factors : Transfusion studies in factor - deficient patients

E. J. W. BOWIE, J. H. THOMPSON, P. DiDi-SHEIM
Transfusion • 1966

ministration of tritiated digoxin with and without a loading dose : A metabolic study

F. I. MARCUS, J. PAVLOVICH, L. BURKHALTER
Circulation • 1966

Anticoagulant prophylaxis and treatment of venous thromboembolism

S. SEVIrT
Proceedings of Conference on Thrombosis , November 28 - 30 , 1967 . Washington , D . C . , National Research Council and the International Committee for Hemostasis and Thrombosis • 1964

Stuart - Prower factor assay and its clinical significance

F. BACHMANN, F. DUCKERT, F. AND KOLLER
Thromb Diath Haemorrh • 1964

Studies on the coumarin anticoagulant drugs : Assay of warfarin and its biologic application

R. A. O'REILLY, P. M. AGGELER, M. S. HOAG, L. S. AND LEONG
Thromb Diath Hae - morrh • 1964