Studies on congenital osteopetrosis in microphthalmic mice using organ cultures: impairment of bone resorption in response to physiologic stimulators

@article{Raisz1977StudiesOC,
  title={Studies on congenital osteopetrosis in microphthalmic mice using organ cultures: impairment of bone resorption in response to physiologic stimulators},
  author={Lawrence G. Raisz and Hollis A. Simmons and Susan Gworek and Gabriel F. Eilon},
  journal={The Journal of Experimental Medicine},
  year={1977},
  volume={145},
  pages={857 - 865}
}
The mechanism of congenital osteopetrosis in microphthalmic (mi) mice has been examined in bone organ cultures. Resorption was measured by the release of previously incorporated 45Ca in fetal long bones and newborn calvaria from mi mice and heterozygous or homozygous normal litter mates. Bones from mi mice showed a generalized resorption defect with decreased spontaneous or control resorption and failure to respond to parathyroid hormone (PTH), prostaglandin E2, 1,25 dihydroxy vitamin D3… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 22 references

Experimental osteopetrosis

  • D. G. Walker
  • Clin. Orthop. Relat. Res
  • 1975
2 Excerpts

Partial purifica on M ay 1, 2017 D ow nladed fom Published April

  • R. A. Luben, G. R. Mundy, C. L. Trummel, L. G. Raisz
  • AND G. EILON
  • 1974
2 Excerpts

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