Studies on chymotrypsin-like catalysis by synthetic peptides

@article{Corey1994StudiesOC,
  title={Studies on chymotrypsin-like catalysis by synthetic peptides},
  author={Michael J. Corey and Eva Hallakova and Kathleen C. Pugh and John M Stewart},
  journal={Applied Biochemistry and Biotechnology},
  year={1994},
  volume={47},
  pages={199-212}
}
The synthetic peptide Chymohelizyme-1 (CHZ-1) exhibits esterase activity against carbobenzoxytyrosinep-nitrophenyl ester (ZTONP), carbobenzoxyalaninep-nitrophenyl ester (ZAONP), andt-butyloxycarbonyltyrosinep-nitrophenyl ester (BocTONP). However, earlier reports of catalytic activity against less labile esters and amides have proven to be incorrect. The major reason for the errors appears to have been the omission of certain controls in the previous work. Although the catalytic triad does not… 
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