OBJECTIVE To investigate the chemical constituents of Desmos chinensis. METHOD Various column chromatographic techniques were employed for the isolation and purification of constituents from the ethanol extract. The structures were elucidated by spectral analysis. RESULT Eleven compounds were isolated and identified as lawinal(1), desmosal(2), desmethoxymatteucinol(3), unonal(4), isounonal(5), desmosflavone(6), allantoic acid(7), succinic acid(8), daucosterol(9), beta-sitosterol(10) and stearic acid(11). The structures of compounds 1 and 2 were reconfirmed by NOEDS technique. CONCLUSION Compound 2 is a new natural product and 7, 8 and 9 were found from this plant for the first time.