Studies on binding and mitogenic effect of insulin and insulin-like growth factor I in glomerular mesangial cells.

Abstract

The mesangial cells, as part of their smooth muscle cell function, are actively involved in regulating glomerular hemodynamics. Their overlying endothelium is fenestrated; therefore, these cells are directly exposed to plasma substances, including hormones such as insulin and insulin-like growth factor I (IGF-I). These peptides may contribute to the… (More)

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