Studies on antigens useful for detection of IgE antibodies in isocyanate-sensitized workers.

@article{Dewair1982StudiesOA,
  title={Studies on antigens useful for detection of IgE antibodies in isocyanate-sensitized workers.},
  author={Mahmoud A. Dewair and Xaver Baur},
  journal={Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie},
  year={1982},
  volume={20 6},
  pages={337-40}
}
Toluene diisocyanate was conjugated by two different methods to human serum albumin. These conjugates were used as antigens in the radio-allergo-sorbent-test (RAST) for detection of IgE antibodies in sera of isocyanate-sensitized persons. Chemical analyses have shown that conjugates containing 18-28 mol of isocyanate residues per mol protein were more potent antigens than those containing greater amounts of isocyanate residues. These results were confirmed by RAST inhibition experiments. The… CONTINUE READING

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