Studies on antiallergy agents. III. Synthesis of 2-anilino-1,6-dihydro-6-oxo-5-pyrimidinecarboxylic acids and related compounds.

Abstract

A series of 2-anilino-1,6-dihydro-6-oxo-5-pyrimidinecarboxylic acids with various substituents was synthesized and evaluated in the rat passive cutaneous anaphylaxis test for antiallergic activity. High activity by intraperitoneal and oral administrations was observed for the 3-trifluoromethyl and 2-alkoxyanilino derivatives (64, 79, 81, 82 and 85… (More)

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@article{Ozeki1989StudiesOA, title={Studies on antiallergy agents. III. Synthesis of 2-anilino-1,6-dihydro-6-oxo-5-pyrimidinecarboxylic acids and related compounds.}, author={Kenji Ozeki and Takafumi Ichikawa and Hiro-o Takehara and Keiichi Tanimura and Masaaki Sato and Hiroshi Yaginuma}, journal={Chemical & pharmaceutical bulletin}, year={1989}, volume={37 7}, pages={1780-7} }