Studies on a new immunoactive peptide, FK-156. II. Fermentation, extraction and chemical and biological characterization.

@article{Gotoh1982StudiesOA,
  title={Studies on a new immunoactive peptide, FK-156. II. Fermentation, extraction and chemical and biological characterization.},
  author={T. Gotoh and K. Nakahara and T. Nishiura and M. Hashimoto and T. Kino and Y. Kuroda and M. Okuhara and M. Kohsaka and H. Aoki and H. Imanaka},
  journal={The Journal of Antibiotics},
  year={1982},
  volume={35},
  pages={1286-1292}
}
: An interesting immunoactive peptide, FK-156, has been isolated from the fermentation broth of Streptomyces olivaceogriseus sp. nov. and Streptomyces violaceus. The compound was purified by column chromatography with activated carbon, ion exchange Sephadex and cellulose powder. FK-156, obtained as white powder, exhibits a wide variety of immunostimulatory activity in vivo and in vitro with experimental animals. Pretreatment of mice or rats with this peptide protected the animals against lethal… Expand
Studies on a new immunoactive peptide, FK-156. I. Taxonomy of the producing strains.
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Two strains of actinomycetes produce a new biologically active substance, designated FK-156, and are identified as Streptomyces olivaceogriseus sp. Expand
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