Studies on a new epidermal growth factor-receptor kinase inhibitor, erbstatin, produced by MH435-hF3.

@article{Umezawa1986StudiesOA,
  title={Studies on a new epidermal growth factor-receptor kinase inhibitor, erbstatin, produced by MH435-hF3.},
  author={Hamao Umezawa and Masaya Imoto and Tsutomu Sawa and Kunio Isshiki and Naoko Matsuda and Takeshi Uchida and Hironobu Iinuma and Masa Shuwarejidense Hamada and Tomio Takeuchi},
  journal={The Journal of antibiotics},
  year={1986},
  volume={39 1},
  pages={
          170-3
        }
}
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211 Citations
Background Citations
18
Methods Citations
2

211 Citations

Citation Type

Citation Type

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It is demonstrated that inhibition of SapM with small molecule inhibitors is efficient in reducing intracellular mycobacterial survival in host macrophages and confirmed SapM as a potential therapeutic target.
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  • 2019
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The research on nucleoside antibiotics mainly done by Isono and his collaborators is summarized from the discovery of polyoxin to subsequent investigations.
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A screening to discover new MEK inhibitors was performed, and a guanine derivative produced by Streptomyces sp.
Chemistry and biology for the small molecules targeting characteristics of cancer cells
  • M. Imoto
  • Chemistry, Biology
    Bioscience, biotechnology, and biochemistry
  • 2018
TLDR
Chemical biology is a remarkable approach in which small molecules are used as probes to elucidate protein functions related to cancer development, and natural products are ideal screening sources due to their structural diversity.
Professor Hamao Umezawa opened up a new road for the development of molecularly targeted therapeutic drugs for cancers
  • M. Imoto
  • Biology
    The Journal of Antibiotics
  • 2018
This issue is dedicated to Prof Hamao Umezawa in appreciation of his great contributions to pioneering research on antibiotics targeting oncogenes.
Bioprobes at a Glance
This chapter provides the fact database of bioprobes that have been reported. 1. The “Bioprobes at a Glance” section is ordered alphabetically by entry name. 2. A compound with an…
Chapter 8 - Protein Kinase Inhibitors from Microorganisms
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References

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The EGF-MolecularWeight Form of mEGF and the Synthesis of Extracellular Macromolecules, and the Biological Effects of EGF and Urogastrone are presented.
The structure of an epidermal growth factor-receptor kinase inhibitor, erbstatin.
Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences
Each of six peptides derived from the human epidermal growth factor (EGF) receptor very closely matches a part of the deduced sequence of the v-erb-B transforming protein of avian erythroblastosis…
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Highly purified preparations of insulin receptor catalyzed the phosphorylation of the 95,000-dalton subunit of the insulin receptor, suggesting that the insulin receptors is itself a protein kinase.
Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor.
A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles.
Affinity labeling of the protein kinase associated with the epidermal growth factor receptor in membrane vesicles from A431 cells.
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