Studies on a new epidermal growth factor-receptor kinase inhibitor, erbstatin, produced by MH435-hF3.

@article{Umezawa1986StudiesOA,
  title={Studies on a new epidermal growth factor-receptor kinase inhibitor, erbstatin, produced by MH435-hF3.},
  author={Hamao Umezawa and Masaya Imoto and Tsutomu Sawa and Kunio Isshiki and Naoko Matsuda and Takeshi Uchida and Hironobu Iinuma and Masa Shuwarejidense Hamada and Tomio Takeuchi},
  journal={The Journal of antibiotics},
  year={1986},
  volume={39 1},
  pages={
          170-3
        }
}
Bio-Guided Isolation of Antimalarial Metabolites from the Coculture of Two Red Sea Sponge-Derived Actinokineospora and Rhodococcus spp.
TLDR
The effectiveness of coculture was confirmed in the discovery of microbial metabolites yet to be discovered in the axenic fermentation with the potential that could be comparable to adding chemical signalling molecules in the fermentation flask.
Discovery of uncompetitive inhibitors of SapM that compromise intracellular survival of Mycobacterium tuberculosis
TLDR
It is demonstrated that inhibition of SapM with small molecule inhibitors is efficient in reducing intracellular mycobacterial survival in host macrophages and confirmed SapM as a potential therapeutic target.
Discovery and applications of nucleoside antibiotics beyond polyoxin
  • H. Osada
  • Chemistry
    The Journal of Antibiotics
  • 2019
TLDR
The research on nucleoside antibiotics mainly done by Isono and his collaborators is summarized from the discovery of polyoxin to subsequent investigations.
A guanine derivative as a new MEK inhibitor produced by Streptomyces sp. MK63-43F2
TLDR
A screening to discover new MEK inhibitors was performed, and a guanine derivative produced by Streptomyces sp.
Chemistry and biology for the small molecules targeting characteristics of cancer cells
  • M. Imoto
  • Chemistry, Biology
    Bioscience, biotechnology, and biochemistry
  • 2018
TLDR
Chemical biology is a remarkable approach in which small molecules are used as probes to elucidate protein functions related to cancer development, and natural products are ideal screening sources due to their structural diversity.
Professor Hamao Umezawa opened up a new road for the development of molecularly targeted therapeutic drugs for cancers
  • M. Imoto
  • Biology
    The Journal of Antibiotics
  • 2018
This issue is dedicated to Prof Hamao Umezawa in appreciation of his great contributions to pioneering research on antibiotics targeting oncogenes.
Bioprobes at a Glance
This chapter provides the fact database of bioprobes that have been reported. 1. The “Bioprobes at a Glance” section is ordered alphabetically by entry name. 2. A compound with an
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References

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Epidermal growth factor
  • S. Cohen
  • Biology, Chemistry
    In vitro cellular & developmental biology : journal of the Tissue Culture Association
  • 1987
TLDR
The EGF-MolecularWeight Form of mEGF and the Synthesis of Extracellular Macromolecules, and the Biological Effects of EGF and Urogastrone are presented.
Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences
Each of six peptides derived from the human epidermal growth factor (EGF) receptor very closely matches a part of the deduced sequence of the v-erb-B transforming protein of avian erythroblastosis
Cellular oncogenes and retroviruses.
  • J. Bishop
  • Biology, Medicine
    Annual review of biochemistry
  • 1983
Devoilement des oncogenes cellulaires: strategies experimentales et definitions. Caracteristiques structurales. Phylogenese. Expressions. Fonctions. Familles d'oncogenes cellulaires. Linkages.
Insulin receptor: evidence that it is a protein kinase.
TLDR
Highly purified preparations of insulin receptor catalyzed the phosphorylation of the 95,000-dalton subunit of the insulin receptor, suggesting that the insulin receptors is itself a protein kinase.
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