Studies on a new antiallergic pyridinecarboxamide TA-5707F and its sodium salt (TA-5707). II. Mechanism of antiallergic action of TA-5707.

@article{Tsuzurahara1987StudiesOA,
  title={Studies on a new antiallergic pyridinecarboxamide TA-5707F and its sodium salt (TA-5707). II. Mechanism of antiallergic action of TA-5707.},
  author={K. Tsuzurahara and S. Ishikawa and Y. Ono and T. Murata and M. Kikuchi and S. Takeyama},
  journal={Japanese journal of pharmacology},
  year={1987},
  volume={45 1},
  pages={
          55-62
        }
}
Mechanism of the antiallergic action of 6-methyl-N-(1H-tetrazol-5-yl)-2-pyridinecarboxamide (TA-5707F) was studied using the water-soluble sodium salt (TA-5707). 1) TA-5707 administered p.o. at the dose ca. 3 times the ID50 for the PCA reaction did not inhibit capillary dye leakage induced on the rat skin by intracutaneous injection of histamine, serotonin, bradykinin and leukotriene D4 (LTD4). 2) TA-5707, at concentrations above 10(-7) M, inhibited antigen-induced histamine release and dye… Expand
1 Citations
N,N′‐[(2,3,5,6‐Tetra­fluoro‐1,4‐phenyl­ene)dimethyl­ene]bis­(pyridine‐4‐carboxamide)
The title compound, C20H14F4N4O2, has been synthesized as part of our ongoing investigations into three-dimensional supra­molecules or polymers with intriguing structural topologies and properties.Expand

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Studies on a new antiallergic pyridinecarboxamide TA-5707F and its sodium salt (TA-5707). I. Inhibition of IgE-induced passive cutaneous anaphylaxis (PCA) in rats.
TLDR
Both TA- 5707 and TA-5707F were found to be orally effective inhibitors of rat PCA and maximum activity by oral administration was obtained when they were administered 5 min before the challenge, and under these conditions were both approximately 1 mg/kg. Expand
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TLDR
The clinical effect of a new orally active anti-allergic agent, coded TA-5707 and chemically designed as 6-methyl-N-(1H-tetrazol-5-y1)-2-pyridine carboxamide sodium salt, was investigated in 12 male patients with allergic rhinitis, finding the inhibitory effect was stronger after 2 hr of administration than after 1hr of administration. Expand
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