Studies on a growth-inhibitory peptide derived from alpha-fetoprotein and some analogs.

@article{Eisele2001StudiesOA,
  title={Studies on a growth-inhibitory peptide derived from alpha-fetoprotein and some analogs.},
  author={Leslie E. Eisele and Fassil B. Mesfin and James P. Bennett and Thomas Hestb{\ae}k Andersen and Herbert I. Jacobson and H Soldwedel and Robert Maccoll and Gerald J. Mizejewski},
  journal={The journal of peptide research : official journal of the American Peptide Society},
  year={2001},
  volume={57 1},
  pages={29-38}
}
A 34-amino acid synthetic peptide was derived from the third domain of human alpha-fetoprotein, and the peptide was shown to inhibit estrogen-stimulated growth. Under certain conditions, however, the peptide lost growth-inhibitory activity. A biophysical study of the peptide was undertaken with a goal of obtaining completely reliable preparations. The peptide was studied using gel-filtration column chromatography as a function of peptide concentration and age of solution, and was found to… CONTINUE READING

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