Studies on Thrombin-induced Platelet Agglutination

  title={Studies on Thrombin-induced Platelet Agglutination},
  author={Richard W. Shermer and Reginald G. Mason and Robert H. Wagner and Kenneth M. Brinkhous},
  journal={The Journal of Experimental Medicine},
  pages={905 - 920}
A one-stage macroscopic test for platelet agglutination was used to study the effect of thrombin and thrombin-cation mixtures on washed platelets. Conclusions regarding platelet agglutination are as follows: (a) Canine, bovine, or human thrombin alone does not cause agglutination of canine or human platelets. (b) Thrombin with calcium or magnesium causes rapid platelet agglutination. Both calcium and magnesium are active at physiologic concentrations. Divalent manganese or cadmium ions can be… CONTINUE READING
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