Studies on Structure-Activity Relationship of Nonquaternary AChE Reactivators

@inproceedings{1993StudiesOS,
  title={Studies on Structure-Activity Relationship of Nonquaternary AChE Reactivators},
  author={焦克芳 and 宋鸿锵 and 卜志洁},
  year={1993}
}
A series of dialkylaminoalkyl thioesters of α-keto thiohydroximic acid (4-RC_6H_4-COC·(NOH)-S-(CH_2)_n-NR′R″) as acetylcholinesterase (ACHE) reactivators in vitro were reported, whose correlations between oxime acid(α-keto thiohydromate acid) dissociation constants (pKa), Hammett values(σp) and rate of AChE reactivation were discussed by Bedford etal. They were considered as nonquaternary AChE reactivators based on the classical reactivative theory by the authors.