Studies on Bacillus stearothermophilus. Part II. Transformation of progesterone.

  title={Studies on Bacillus stearothermophilus. Part II. Transformation of progesterone.},
  author={Sameera Al-Awadi and Mohd. Afzal and Sosamma Oommen},
  journal={The Journal of steroid biochemistry and molecular biology},
  volume={82 2-3},
Bacillus stearothermophilus, a thermophilic bacterium isolated from Kuwaiti desert, when incubated with exogenous progesterone for 10 days at 65 degrees C produced two new dihydroxy isomers of progesterone, and two known compounds, 5 alpha-pregnane-3,6,20-trione and 6-dehydroprogesterone, along with the earlier reported monohydroxylated metabolites and a B-Seco compound. The two new dihydroxy compounds were identified as 6 alpha,20 alpha-dihydroxyprogesterone and 6 beta,20 alpha… CONTINUE READING

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