Corpus ID: 26877042

Studies of the time-dependent inactivation of aromatase by 4beta,5beta-epoxy-6-one and 5beta,6beta-epoxy-4-one steroids under various conditions.

@article{Numazawa1999StudiesOT,
  title={Studies of the time-dependent inactivation of aromatase by 4beta,5beta-epoxy-6-one and 5beta,6beta-epoxy-4-one steroids under various conditions.},
  author={M. Numazawa and K. Yamada},
  journal={Biological & pharmaceutical bulletin},
  year={1999},
  volume={22 11},
  pages={
          1207-11
        }
}
  • M. Numazawa, K. Yamada
  • Published 1999
  • Medicine
  • Biological & pharmaceutical bulletin
  • The time-dependent inactivation of aromatase by epoxy analogs of the good aromatase inhibitors, androst-4-ene-6,17-dione (3) and androst-5-ene-4,17-dione (7), 4beta,5beta-epoxy and 5beta,6beta-epoxy compounds 10 and 13 and their 19-oxo derivatives 11 and 14, was examined in either the presence or absence of NADPH. The 4beta,5beta-epoxy-19-oxo steroid 11 along with the 19-methyl-5beta,6beta-epoxide 13 inactivated human placental aromatase in a mechanism-based manner, in the presence of NADPH… CONTINUE READING

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