Studies of the relationship of the 230-kD and 180-kD bullous pemphigoid antigens.

@article{Robledo1990StudiesOT,
  title={Studies of the relationship of the 230-kD and 180-kD bullous pemphigoid antigens.},
  author={M. E. Fern{\'a}ndez Robledo and Sun-min Kim and Neil J. Korman and John R. Stanley and Ramzy S. Labib and Shouichi Futamura and Grant James Anhalt},
  journal={The Journal of investigative dermatology},
  year={1990},
  volume={94 6},
  pages={
          793-7
        }
}
In bullous pemphigoid (BP), autoantibodies from most patients recognize a high molecular weight 230-kD epidermal antigen (Ag) by immunoprecipitation. By Western immunoblotting, 50-70% of sera recognize the high molecular weight Ag, but 30-50% recognize a low molecular weight, 180-kD epidermal Ag. We examined the specificities of affinity-purified antibodies against these Ag. Antibodies specific for the 230- and 180-kD Ag were prepared by immunoaffinity against Ag immobilized on nitrocellulose… CONTINUE READING
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